SunVax mRNA Therapeutics
SV101 Delivery™ Mouse T cell targeted
SV101 Delivery™ Mouse T cell targeted
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SunVax is a pioneering biotechnology company located in the Greater Boston area, specializing in the development of advanced lipid nanoparticle (LNP) delivery systems and self-amplifying mRNA (samRNA) platforms. Leveraging a proprietary library of over one million molecular structures, SunVax has synthesized and screened more than 60,000 ionizable lipids through high-throughput methods. To accelerate progress in the mRNA research community, SunVax launched a series of ready-to-use mouse/human T cell and CD8 T cell specific delivery LNP kits for research use only for proof-of-concept and screening mRNA constructs ex vivo (in mouse splenic cells, or in human PBMC cells), and in vivo (mouse or humanized mouse).
Cell-type specificity: Enabling targeted delivery to mouse T cells with exceptional selectivity.
Mouse T cell targeted SV101 Delivery™ Kit information and Supporting Data
Table 1 The Characterizations of mouse T cell targeted LNP-mRNA generated by SV101 Delivery™ Kit
|
LNP-mRNA |
EE (%) |
Size (nm) |
PDI |
|
SV101 Delivery™ |
99.2±0.6 |
99.2±0.9 |
0.17±0.01 |
The kits exhibit excellent encapsulation efficiency, generate nanoparticles with a uniform average size of approximately 100 nm, and maintain a low polydispersity index (PDI).
Figure 1. Stability of mouse T cell targeted LNP-mRNA generated by SV101 Delivery™ Kit. The mouse T cell targeted LNP-mRNA underwent three freeze–thaw cycles prior to transfect mouse splenic cells. Shown are nanoparticle size (A), polydispersity index (PDI) (B), and transfection efficiency in mouse splenic cells (C).
Figure 2. The SV101 Delivery™ kit demonstrated robust transfection efficiency and cell-type specificity in mouse splenic cells. In vitro transfection efficacy: Mouse splenic cells were transfected with LNP–mRNA encoding eGFP, formulated using the SV101Delivery™ kit as indicated. Shown are representative FACS plots (A) and the percentage of GFP⁺ cells (B) one day post-transfection, as determined by flow cytometry.
Store Temperature
Lipid Mixture: -80°C
Formulation Buffer: Room Temperature
Reagent A: -80°C
Reagent B-1: 4°C
